Q

How does body weight affect osteoarthritis?

From 5 years of verified research · Vassili Sandqvist
A

Body weight has a significant impact on osteoarthritis through two primary mechanisms: mechanical loading and adipokine-mediated inflammation. For every kilogram of body weight, the compressive force on the knee joint during walking increases by 3–6 times, and excess adipose tissue produces inflammatory substances that can impair joint function, even in non-weight-bearing areas.

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