Why is citrulline preferred over arginine for supplementation?
Citrulline is preferred because oral L-arginine is extensively metabolized in the gut and liver, resulting in low bioavailability due to the first-pass effect. In contrast, L-citrulline bypasses this limitation, has high oral bioavailability, and is converted to arginine in the kidneys, effectively raising plasma arginine levels more than oral arginine supplementation.
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