Q

What is the 'Twin Cycle Hypothesis' related to type 2 diabetes?

From 5 years of verified research · Vassili Sandqvist
A

The 'Twin Cycle Hypothesis' posits that excess caloric intake leads to fat accumulation in ectopic locations, such as the liver and pancreas, which in turn causes insulin resistance and beta-cell dysfunction. By reducing liver and pancreatic fat below individual thresholds, it is possible to reverse these cycles and restore normal metabolic function.

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