What is the role of Rhodiola in cortisol regulation?
Rhodiola rosea has a dual effect on cortisol levels, acting through two opposing mechanisms. It can lower cortisol by increasing serotonergic activity, which suppresses ACTH release, or it can raise cortisol by promoting neuropeptide Y release in individuals with low serotonin. The outcome depends on the individual's baseline HPA axis state, which explains the contradictory results in clinical trials.
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