Q

What is the primary action of Metformin in the body?

From 5 years of verified research · Vassili Sandqvist
A

Metformin primarily activates AMPK (AMP-activated protein kinase) in the liver by inhibiting Complex I of the mitochondrial electron transport chain. This activation leads to a reduction in hepatic gluconeogenesis, increased insulin sensitivity, and reduced intestinal glucose absorption, ultimately lowering fasting blood glucose levels.

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