Q

What is the current understanding of the serotonin hypothesis in relation to depression?

From 5 years of verified research · Vassili Sandqvist
A

The serotonin hypothesis, which posits that depression is caused by low serotonin levels, is an oversimplification that has been largely discredited by the psychiatric research community. A 2022 review found weak evidence supporting a direct relationship between serotonin function and depression, indicating that the mechanisms of antidepressant action are more complex, involving neuroplasticity and other factors.

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