What did the 2009 systematic review in the Annals of Internal Medicine conclude about PSA screening?
The review found that PSA screening can reduce prostate cancer mortality by 20–50%, but it also highlighted significant issues with overdiagnosis and overtreatment of clinically insignificant cancers. For every death prevented, approximately 48 men may be identified and treated unnecessarily.
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This is one answer. The complete system — the psychology, the biology, and the method — is in the book.
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