How does the combination of caffeine and green tea extract (EGCG) work?
The combination of caffeine and EGCG is synergistic; EGCG inhibits catechol-O-methyltransferase (COMT), which degrades epinephrine. This prolongs the catecholamine signal initiated by caffeine, resulting in a modest but significant additional fat oxidation and thermogenic effect compared to caffeine alone.
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